Clinical Chemistry - No Interference by Diclofenac with the New Vitros FT3II Assay Reagent
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Measurements of serum concentrations of free triiodothyronine (FT^sub 3^), thyroid-stimulating hormone (TSH), and free thyroxine (FT^sub 4^) are useful in the diagnosis and treatment of thyroid diseases. Several nonsteroidal antiinflammatory drugs (NSAIDs) are known to interfere with thyroid function tests (1,2). Cross-reaction with the assay antibody is one of the mechanisms of NSAlD interference (3). The FT^sub 3^ antibody included in the Vitros FT^sub 3^ assay (Ortho-Clinical Diagnostics Inc.) cross-reacts with diclofenac, a phenylacetic acid derivative with structural …
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