A gravimetric method for the determination of diclofenac in pharmaceutical preparations was developed. Diclofenac is precipitated from aqueous solution with copper(II) acetate in pH 5.3 (acetic acid/acetate buffer). Sample aliquots had approximately the same quantity of the drug con…
The aim of this study was to compare the efficacy and safety of an oral enzyme-rutosid combination (ERC) containing rutosid and the enzymes bromelain and trypsin, with that of diclofenac in patients with osteoarthritis (OA) of the knee. A total of 103 patients presenting with painful episodes of OA of the knee were treated for 6 weeks in two study centers in a randomized, double-blind, parallel group trial…
Trial Successful, Javelin Pharmaceuticals on Track to Submit New Drug Application to US FDA in 2009
CAMBRIDGE, Mass. — Javelin Pharmaceuticals (AMEX: JAV) announced today that its US product candidate Dyloject(TM) (diclofenac sodium for injection) met primary efficacy endpoints with rob…
The Indian government has ordered a crackdown on the illegal use of diclofenac for veterinary purposes, in a last-ditch bid to avert the extinction of vultures threatened by the drug (C&I 2008, 4. 18). Last month, Indian drug controller general Surinder Singh wrote to more…
